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Showing results for alanosine
Your search for alanosin retrieved no results
Alanosine (UCSD).
Yu J. Yu J. Curr Opin Investig Drugs. 2001 Nov;2(11):1623-30. Curr Opin Investig Drugs. 2001. PMID: 11763167 Review.
Alanosine is an amino acid analog originally derived from Streptomyces alanosinicus. ...In early 1997, patients were being recruited for a phase II pilot efficacy trial of alanosine as a treatment for glioma and NSCLC, since a significant number of these tumor types …
Alanosine is an amino acid analog originally derived from Streptomyces alanosinicus. ...In early 1997, patients were being recruited …
Biosynthesis of the N-N-Bond-Containing Compound l-Alanosine.
Wang M, Niikura H, He HY, Daniel-Ivad P, Ryan KS. Wang M, et al. Angew Chem Int Ed Engl. 2020 Mar 2;59(10):3881-3885. doi: 10.1002/anie.201913458. Epub 2020 Jan 23. Angew Chem Int Ed Engl. 2020. PMID: 31823464
We here report the biosynthetic pathway for the diazeniumdiolate-containing amino acid l-alanosine. Our work reveals that the two nitrogen atoms in the diazeniumdiolate of l-alanosine arise from glutamic acid and aspartic acid, and we clarify the early steps of the …
We here report the biosynthetic pathway for the diazeniumdiolate-containing amino acid l-alanosine. Our work reveals that the two nit …
The l-Alanosine Gene Cluster Encodes a Pathway for Diazeniumdiolate Biosynthesis.
Ng TL, McCallum ME, Zheng CR, Wang JX, Wu KJY, Balskus EP. Ng TL, et al. Chembiochem. 2020 Apr 17;21(8):1155-1160. doi: 10.1002/cbic.201900565. Epub 2019 Dec 19. Chembiochem. 2020. PMID: 31643127 Free PMC article.
Herein we describe the discovery of a biosynthetic gene cluster in Streptomyces alanosinicus ATCC 15710 responsible for producing the diazeniumdiolate natural product l-alanosine. Gene disruption and stable isotope feeding experiments identified essential biosynthetic gene …
Herein we describe the discovery of a biosynthetic gene cluster in Streptomyces alanosinicus ATCC 15710 responsible for producing the diazen …
Reductases Produce Nitric Oxide in an Alternative Pathway to Form the Diazeniumdiolate Group of l-Alanosine.
Wang M, Ryan KS. Wang M, et al. J Am Chem Soc. 2023 Aug 2;145(30):16718-16725. doi: 10.1021/jacs.3c04447. Epub 2023 Jul 21. J Am Chem Soc. 2023. PMID: 37478476
l-Alanosine is a diazeniumdiolate (N-nitrosohydroxylamine) antibiotic that inhibits MTAP-deficient tumor cells by blocking de novo adenine biosynthesis. Previous work revealed the early steps in the biosynthesis of l-alanosine. In the present study, we used genome m …
l-Alanosine is a diazeniumdiolate (N-nitrosohydroxylamine) antibiotic that inhibits MTAP-deficient tumor cells by blocking de novo ad …
Purine Synthesis Inhibitor L-Alanosine Impairs Mitochondrial Function and Stemness of Brain Tumor Initiating Cells.
Singh SX, Yang R, Roso K, Hansen LJ, Du C, Chen LH, Greer PK, Pirozzi CJ, He Y. Singh SX, et al. Biomedicines. 2022 Mar 23;10(4):751. doi: 10.3390/biomedicines10040751. Biomedicines. 2022. PMID: 35453502 Free PMC article.
Exploiting MTAP loss-conferred deficiency in purine salvage, we demonstrate that purine blockade via treatment with L-Alanosine (ALA), an inhibitor of de novo purine synthesis, attenuates stemness of MTAP-deficient GBM cells. ...
Exploiting MTAP loss-conferred deficiency in purine salvage, we demonstrate that purine blockade via treatment with L-Alanosine (ALA) …
Alanosine toxicity in Novikoff rat hepatoma cells due to inhibition of the conversion of inosine monophosphate to adenosine monophosphate.
Graff JC, Plagemann PG. Graff JC, et al. Cancer Res. 1976 Apr;36(4):1428-40. Cancer Res. 1976. PMID: 177207
However, the alanosine inhibition is not prevented by aspartic acid, even at a concentration of 1 mM. ...Pyrimidine nucleotide synthesis is not significantly inhibited by alanosine, since the uridine triphosphate pool is not affected and uridine fails to reverse the …
However, the alanosine inhibition is not prevented by aspartic acid, even at a concentration of 1 mM. ...Pyrimidine nucleotide synthe …
Identification of gene expression profiles predicting tumor cell response to L-alanosine.
Efferth T, Gebhart E, Ross DD, Sauerbrey A. Efferth T, et al. Biochem Pharmacol. 2003 Aug 15;66(4):613-21. doi: 10.1016/s0006-2952(03)00341-1. Biochem Pharmacol. 2003. PMID: 12906926
Analysis of cell doubling times and IC(50) values for L-alanosine showed that slowly growing cell lines were more resistant to L-alanosine than rapidly growing ones. ...None of the multidrug-resistant cell lines was cross-resistant to L-alanosine indicating t …
Analysis of cell doubling times and IC(50) values for L-alanosine showed that slowly growing cell lines were more resistant to L-a …
A Phase I study of the combination N-(phosphonacetyl)-L-aspartate (PALA, NSC-224131) and L-alanosine (NSC-153353) in patients with advanced cancer.
Creagan ET, O'Connell MJ, Kovach JS. Creagan ET, et al. Cancer. 1983 Aug 15;52(4):615-8. doi: 10.1002/1097-0142(19830815)52:4<615::aid-cncr2820520407>3.0.co;2-o. Cancer. 1983. PMID: 6861099
This article reports a Phase I study of combined therapy with N-(phosphonacetyl)-L-aspartate (PALA) and L-alanosine in 26 patients with advanced cancer. Each agent exhibits antitumor effect by enzyme inhibition: PALA blocks pyrimidine biosynthesis by impeding aspartate tra …
This article reports a Phase I study of combined therapy with N-(phosphonacetyl)-L-aspartate (PALA) and L-alanosine in 26 patients wi …
Status of methylthioadenosine phosphorylase and its impact on cellular response to L-alanosine and methylmercaptopurine riboside in human soft tissue sarcoma cells.
Li W, Su D, Mizobuchi H, Martin DS, Gu B, Gorlick R, Cole P, Bertino JR. Li W, et al. Oncol Res. 2004;14(7-8):373-9. doi: 10.3727/0965040041292332. Oncol Res. 2004. PMID: 15301428
The IC50 values for L-alanosine and MMPR were >20-fold lower in MTAP-deficient cells than in MTAP-positive cells. Restoration of MTAP into HT-1080 MTAP-deficient cells also led to decreased sensitivity to L-alanosine and MMPR. An in vivo study using HT-1080 cell …
The IC50 values for L-alanosine and MMPR were >20-fold lower in MTAP-deficient cells than in MTAP-positive cells. Restoration of M …
120 results